﻿<?xml version="1.0" encoding="utf-8"?><NPDS Version="2.4.2 (2025-09-13)" xmlns="http://npds.portaldoors.org/schema/pdp/npds#"><!--Nexus-PORTAL-DOORS-Scribe Cyberinfrastructure System (c) 2006-2026 Carl Taswell and the PORTAL-DOORS Project Team--><ClientRequest><URL>https://brainwatch.net/Nexus/CTGaming/?ef=1&amp;lc=20&amp;vf=1</URL><Note /><Question /></ClientRequest><ServerResponse><Status /><Note /><Answer /><Related /><Referred /></ServerResponse><AtlasServer Count="0" /><PortalServer Count="0" /><DoorsServer Count="0" /><NexusServer><NexusService Count="20"><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Citation Cartels, Dismissive Literature Reviews, and Big Money Dominate US Education Policy</Name><Nature /><PrincipalTag>Phelps2025CCDLRBMD</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Phelps2025CCDLRBMD</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag Priority="0">Education policy, standardized testing, dismissive review, citation cartel, censorship.</SupportingTag><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-30T08:08:32Z</CreatedOn><UpdatedOn>2026-04-06T07:10:51Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="3"><Provenance>Public NPDS record with handle 'P8E114K32' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/30/2025 4:14:14 AM.</Provenance><Provenance>Public NPDS record with handle 'P8E114K32' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/27/2026 10:55:18 PM. </Provenance><Provenance>Public NPDS record with handle 'P8E114K32' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 4/6/2026 12:10:51 AM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Extensive Social Connectivity and Cognitive Instabilit</Name><Nature /><PrincipalTag>Mizraji2026SCCS</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Mizraji2026SCCS</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag /><SupportingTag Priority="0">Complexity vs. stability in complex networks; stabilization procedures in highly connected networks; instability and stability in highly connected social communities.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-03-04T08:38:39Z</CreatedOn><UpdatedOn>2026-04-06T00:47:26Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="6"><OtherText /><OtherText /><OtherText /><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="6"><Provenance>Public NPDS record with handle 'W799E6AEE' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 4/5/2026 5:47:25 PM. </Provenance><Provenance>Public NPDS record with handle 'W799E6AEE' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/29/2026 11:06:02 PM. </Provenance><Provenance>Public NPDS record with handle 'W799E6AEE' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/25/2026 12:43:14 AM. </Provenance><Provenance>Public NPDS record with handle 'W799E6AEE' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/25/2026 12:42:58 AM. </Provenance><Provenance>Public NPDS record with handle 'W799E6AEE' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/24/2026 10:30:07 PM. </Provenance><Provenance>Public NPDS record with handle 'W799E6AEE' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/5/2026 1:59:55 AM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>From Play to Precision Care: Clinical Telegaming Biomarkers to Evaluate Medication Efficacy for Improving Multiple Sclerosis Patients' Quality of Life</Name><Nature /><PrincipalTag>Shigyo2025FPTPC</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Shigyo2025FPTPC</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag Priority="0">Multiple sclerosis,  clinical telegaming,  digital biomarkers,  precision care,  quality of life.</SupportingTag><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-07T04:11:26Z</CreatedOn><UpdatedOn>2026-04-05T03:03:07Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="4"><Provenance>Review of "From Play to Precision Care: Clinical Telegaming Biomarkers to Evaluate Medication Efficacy for Improving Multiple Sclerosis Patients' Quality of Life"
The manuscript by Shigyo proposes a three-year research plan to develop a home-based clinical telegaming system for individuals with multiple sclerosis (MS). The system aims to extract digital biomarkers related to motor and social-behavioral functioning to evaluate the efficacy of disease-modifying therapies (DMTs). The strength of this proposal lies in its practical approach to addressing the limitations of brief, in-clinic assessments by utilizing continuous, ecologically valid data collected in everyday contexts.
Please find my specific comments below:
1.	Challenges and accessibility: Related work, especially Adiwangsa et al., specifies physical constraints in MS exergaming, such as vertigo and the physical location of device power buttons. This manuscript would benefit from explaining how the proposed system will address these limitations. Considering Adiwangsa's recommendation of a hybrid model combining home and clinic-based use, the author should clarify if this system is strictly for unassisted home use or if it initially involves clinical supervision.
2.	Indicators and constructs: The manuscript mentions measuring motor performances (limb coordination, balance, movement smoothness, reaction speed) and social-behavioral performances (cooperative play, turn-taking, caregiver-patient coordination). Detailed explanation on why each indicator is chosen and which clinical constructs they represent will strengthen the research plan.
3.	Measurement models: Related to the point above, the author should consider addressing the specific measurement models used to measure these latent constructs. Defining this early can also be a point of discussion during the proposed co-design phase.
4.	Hardware and equipment: Adiwangsa et al. highlighted that MS patients often rely on specialized equipment, such as vibration platforms or electrical stimulation. The author should clarify if the telegaming system will integrate physical, tangible objects or specialized MS equipment, as object manipulation helps translate rehabilitation progress to daily activities.
5.	Social interaction: The plan to measure cooperative play is noted. However, given the varying mobility levels in MS, synchronous multiplayer gaming might be difficult. The author should discuss how social interaction will be implemented, perhaps considering asynchronous interaction as suggested by Adiwangsa et al. to accommodate different physical capabilities.
6.	Longitudinal analysis: In the biomarker development section, it is worth mentioning that due to the longitudinal design, this work can perform within-individual analysis. Explaining the statistical approach regarding how individual biomarkers change over time versus how they differ across individuals will support the 'N-of-1' precision care approach mentioned in the text.
7.	Workflow clarification: In the feasibility and validation section, the author notes that feasibility studies will be conducted after the system reaches "functional stability". Please elaborate on what functional stability entails using measurable metrics. Furthermore, the workflow logic needs clarification: feasibility (e.g., deciding game tasks and indicators during co-design) should ideally be determined before assessing functional stability to avoid wasted development effort.
8.	Reliability and validity: The manuscript states this phase will evaluate reliability and convergent validity. It is worth explaining how these will be measured. For instance, will reliability be assessed through multiple sessions within individuals? For validity, specify which established in-clinic motor assessments or caregiver reports will serve as the founcational metrics.
9.	Participants and Sampling: Overall, the manuscript requires a more detailed plan regarding the participants. Defining inclusion and exclusion criteria, target demographics, and the estimated sample size is necessary to properly assess the feasibility, reliability, and validity of the proposed design.

Public NPDS record with handle 'B3D757EF9' accessed in 'Brainiacs Diristry' by user with alias 'B14A25' on 3/2/2026 1:32:31 PM. </Provenance><Provenance>Public NPDS record with handle 'B3D757EF9' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 1/9/2026 10:16:44 PM.</Provenance><Provenance>Public NPDS record with handle 'B3D757EF9' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/18/2025 4:49:28 AM.</Provenance><Provenance>Public NPDS record with handle 'B3D757EF9' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 4/4/2026 8:03:07 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>From the 'Best of Our Knowledge' to the 'Best Available Knowledge'</Name><Nature /><PrincipalTag>CRAIG2025FBOKTBAK</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/CRAIG2025FBOKTBAK</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag /><SupportingTag Priority="0">Data stewardship, metadata management, knowledge engineering, research ethics, citational justice.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-11-06T04:37:44Z</CreatedOn><UpdatedOn>2026-04-05T01:31:20Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="5"><OtherText /><OtherText /><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="5"><Provenance>Public NPDS record with handle 'U90B95F7E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/22/2025 10:52:49 PM.</Provenance><Provenance>Public NPDS record with handle 'U90B95F7E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 4/4/2026 6:31:20 PM. </Provenance><Provenance>Public NPDS record with handle 'U90B95F7E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 1/9/2026 10:14:31 PM.</Provenance><Provenance>Public NPDS record with handle 'U90B95F7E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/11/2025 4:27:31 AM.</Provenance><Provenance>Public NPDS record with handle 'U90B95F7E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/22/2025 10:57:31 PM.</Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>The Logics Behind Reliable and Trustworthy Neuro-Symbolic Artificial Intelligence</Name><Nature /><PrincipalTag>BeimGraben2026LBRTNSAI</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/BeimGraben2026LBRTNSAI</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-03-30T08:25:52Z</CreatedOn><UpdatedOn>2026-04-01T03:57:56Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'R7EF2883B' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/30/2026 2:11:03 AM. </Provenance><Provenance>Public NPDS record with handle 'R7EF2883B' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/31/2026 8:57:56 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Video Understanding of Complex Human Activities</Name><Nature /><PrincipalTag>Balazia2025VUCHA</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Balazia2025VUCHA</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag Priority="0">Video understanding, pattern recognition, human behavior analysis, social interactions, psychiatric phenotyping.</SupportingTag><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-14T08:22:30Z</CreatedOn><UpdatedOn>2026-03-28T10:54:53Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="4"><Provenance>Public NPDS record with handle 'F3DAD390E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/14/2025 2:23:28 AM.</Provenance><Provenance>Public NPDS record with handle 'F3DAD390E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 1/9/2026 10:21:06 PM.</Provenance><Provenance>Public NPDS record with handle 'F3DAD390E' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/28/2026 3:54:53 AM. </Provenance><Provenance>Overall, the authors showcase five datasets of annotated audio and video recordings and machine learning classifiers that make use of them.
The unifying theme is utility for some biomedical purpose.
Four of the five focus on emotional expression and attention with the purpose of aiding psychiatric analysis.
The remaining dataset consists of recordings of surgery and showcases automated identification of surgical implements.

While the creation and curation of each of these datasets represents a major undertaking and may support many future innovations in data analysis in the relevant problem domain, the presentation may not make their value clear to the intended readership.

Specifically, Brainiacs Journal takes an inclusive approach, promoting education and discussion among a diverse readership.
On the one hand, when discussing machine learning methods, the authors just list pipeline components without explaining clearly which ones they have newly developed and which ones already exist or why they chose those components.
On the other, the authors omit information that would be necessary to convince clinicians (e.g., age and gender distribution of patients, qualifications of experts providing the annotations) and statisticians (e.g., statistical test used, correction for multiple hypothesis testing).
Consider rewriting sections about the machine learning methods in a way that makes clear how your innovations make the methods suitable to the problem.
If you have published the pipelines somewhere else, it is acceptable to gloss over implementation details here and cite those other works.

Also, the authors' intent seems to be to publish the datasets introduced here so that others can build on their work, but they do not indicate how to access the data.

Specific comments:
p.x.c.y.l.z. -&gt; page x, column y, line z
Line numbers start at the first body text of the introduction and continue to the end instead of restarting on each page or column.

p.1.c.2.l.12.
You reference MPIIGroupInteraction here and depict it in the figure, but you do not explain how it differs from NOXI or how you use it in your work.
p.1.c.2.l.24.
You do not present these in the present work. Check that you did not just copy and paste in this text from another paper. If you have published these results elsewhere, cite that work.
p.1.c.2.l.30.
What are these fairness analyses? How did you quantify the discrepancies? Relative to what threshold are they "small"?
p.2.c.1.l.48.
How do you ensure that participants in the challenge follow the prescribed train-validation-test split?
p.2.c.1.l.49.
Who provided the ground truth values of these ratings?
How did they assign ratings?
In other words, did raters follow a specific rating procedure for interpreting tone and body language, or did they just assign numbers to their own subjective impressions?
p.2.c.1.l.69.
This citation did not compile correctly.
p.2.c.1.l.70. [really more about the entire section]
While this is an impressive demonstration of machine learning, it is not clear how this provides real-world value.
Most training videos of surgery used in educational courses should already have descriptions indicating the implements used.
p.2.c.1.l.71.
Consider adding citations for the individual methods: PGI, Go-ELAN, mAP, and NMS IoU.
p.2.c.1.l.80.
This appears to be a very broad summary that assumes detailed prior knowledge of the original YOLO architecture.
It will not make much sense to readers who are not already machine learning experts.
Since the goal of Brainiacs is to inform and engage a broad readership, it would be better to take a more accessible approach. 
If you explain the design in more detail in another paper, you should cite it.
Then, instead of listing a set of methods here, you can explain the novel aspects of your architecture in more conceptual terms.
The goal should be to make clear to readers how your changes make the model better suited to your use case of identifying surgical implements in videos.
p.2.c.2.l.93.
This score is superior to what other score from what other model?
Also, who provided the ground truth labels in the dataset?
p.2.c.2.l.96.
What surgery do the images depict?
p.2.c.2.l.101.
What are some concrete examples of these challenges?
p.2.c.2.l.109.
Substantially more efficient? Compared to what?
p.2.c.2.l.117.
What is this state-of-the-art, and what are the results?
p.2.c.2.l.134.
The placement of references to Figures 5 and 6 in the text seem arbitrary.
Figure 5 shows example still images from the set.
Figure 6 shows the number of samples in each broad category: simple emotion, equal blend, and unequal blend.
The article text should reflect this.
p.3.c.1.l.144.
These numbers seem arbitrary.
How would you distinguish a 70/30 mix of happiness and sadness from a 60/40 mix or a 80/20 mix?
If the mix is not really quantifiable, it would be better to avoid using numbers to implying quantification.
As a counterexample, pain scales use numbers, such as ratings from 1 to 5, to indicate strength of a feeling, but the coarseness of the scale reflects the imprecise and relative nature.
It might be better to do something similar here: 0-4, 1-3, 2-2, 3-1, 4-0.
This gives you the same number of classes and conveys roughly the same meaning without implying decimal-precision measurements.
p.3.c.1.l.154.
Typically, one uses the validation set to compare different choices of hyperparameters.
Choosing the maximum accuracy from this range creates a selection bias.
This is why the validation and testing sets are separate.
What is the testing set accuracy?
p.3.c.1.l.166.
Once again, it is not clear who is providing the gold standard output values. Are they experts or non-experts? Does each rating come from a single rater or a vote among multiple raters?
p.3.c.1.l.187.
What does "psychological recordings" mean here?
EEG?
Heart rate?
Pupil dilation?
p.3.c.1.l.190.
When doing comparisons, do you stratify patients by age and gender?
These can interact with psychiatric disorders and trauma in complex ways.
Not taking these confounds into account may lead to issues.
For example, if a disproportionately large fraction of the schizophrenia patients are male, then the algorithm may end up using features correlated with maleness as biomarkers for schizophrenia, even when they are not indicative of schizophrenia in male humans in the general population.
p.3.c.1.l.193.
Write out the phrases before using the abbreviations.
p.3.c.1.l.194.
What acceleration is the accelerometer measuring?
p.3.c.2.l.198.
How many is "many"?
Have you published the ones that the patients consented to have published?
Where?
p.3.c.2.l.206.
This entire paragraph has a lot of background information but only one citation, which appears to be for a specific detail.
Cite appropriate sources for any information or proposed hypotheses that are not new to this paper.
p.3.c.2.l.237.
Make clear what algorithm or model you are using to create these semantic embeddings.
It is important to avoid confusion among all the different uses of "semantic", such as "semantic web".
p.3.c.2.l.247.
You should do permutation tests to check the significance of the correlations.
p.4.c.1.l.261.
This seems like a large enough imbalance in the data set to cause problems for many machine learning classifiers.
Can you subsample the data or address the imbalance in some other way?
p.4.c.1.l.267.
This concept of an "action unit" may not be familiar to many readers. Consider explaining this and some other features.
p.4.c.1.l.278.
Cite a source for the random forest implementation that you used.
p.4.c.1.l.281.
Does this mean the number of incomplete utterances?
Which condition tends to have more incomplete utterances?
How large is this effect?
p.4.c.1.l.283.
Temporal variability of what?
p.4.c.1.l.285.
Which deep and non-deep machine learning methods are you comparing, simple decision trees and random forests?
p.4.c.1.l.292.
Cite a literature review to support both presence of evidence for speech features as depression biomarkers and the absence of studies on the effect of childhood trauma on these biomarkers.
p.4.c.1.l.297.
How old are the participants?
Are they adults or still children?
p.4.c.2.l.307.
What statistical test did you use?
What significance threshold?
Did you perform multiple hypothesis correction?
For each result you report, can you provide a p-value or effect size?
p.4.c.2.l.320.
Add a conclusion to the paper.
Figure 2.
What does silence mean? Where are the inputs and outputs?
Figure 3.
You cropped the figure too much.
Labels are above bounding boxes.
Consequently, some of the labels in the top row are outside the image frame and get cut off.
It also looks like the bottoms of some bounding boxes in the bottom row and the right sides of some boxes in the right column are cut off.
It looks like the predictions have confidence scores.
How do you calculate these? What is the scale?
Figure 4.
This diagram is also missing inputs and outputs.
Figure 5.
It is not clear which image is which.
Also, since you have 5 possible classes (all fear, mostly fear, equal mix, mostly anger, all anger), it makes sense to have 5 images.
Figure 6.
This figure conveys very little information compared to the space it takes up.
Consider instead expanding it to a full table with the following columns: Category (single, unequal, equal), Primary emotion (or just the alphabetically first emotion for the equal cases), Secondary emotion, Number of training samples, Number of validation samples, Number of testing samples.
Figure 8.
Can you also plot a measure of synchrony along the same time axis?

Public NPDS record with handle 'F3DAD390E' accessed in 'Brainiacs Diristry' by user with alias 'K95FDE' on 2/27/2026 12:38:15 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Newton’s Laws of Motion for Combating Abuses of Power to Ignite Transformation in Anti-Learning Systems (CAPITALS)</Name><Nature /><PrincipalTag>Rubin2025NLMCAPIT</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Rubin2025NLMCAPIT</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag /><SupportingTag Priority="0">Learning health systems, political systems, abuses of power, darvomanic corruption.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-30T13:35:58Z</CreatedOn><UpdatedOn>2026-03-28T06:21:41Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'J6D51R82A' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/27/2026 11:21:40 PM. </Provenance><Provenance>Public NPDS record with handle 'J6D51R82A' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/31/2025 3:19:15 AM.</Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Grokking the Data, Hearing Each Other: Fostering Scholarly Dialogue Through Sound Statistics and Civil Discourse</Name><Nature /><PrincipalTag>Lacey2025GDHEOFSD</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Lacey2025GDHEOFSD</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag /><SupportingTag Priority="0">Civil discourse, scholarly dialogue, statistical data analysis, research integrity.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-25T06:06:39Z</CreatedOn><UpdatedOn>2026-03-27T07:44:18Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'DA46DDE55' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/27/2026 12:44:18 AM. </Provenance><Provenance>Public NPDS record with handle 'DA46DDE55' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/25/2025 2:30:09 AM.</Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Sustaining Academic Publishing During Wartime: Integrity, Collaboration, and Responsibility</Name><Nature /><PrincipalTag>Kharlamova2025SAPDWICR</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Kharlamova2025SAPDWICR</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag /><SupportingTag Priority="0">Open science integration, sustainable scientific publishing, wartime financial strategies.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-21T05:01:13Z</CreatedOn><UpdatedOn>2026-03-27T06:29:09Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="3"><Provenance>Public NPDS record with handle 'Y35290A8A' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/26/2026 11:29:09 PM. </Provenance><Provenance>Public NPDS record with handle 'Y35290A8A' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/20/2025 10:36:09 PM.</Provenance><Provenance>Public NPDS record with handle 'Y35290A8A' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/24/2025 8:28:23 PM.</Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Navigating the Modern Infodemic: Historical Perspectives and Information Science Frameworks as Guideposts</Name><Nature /><PrincipalTag>Zimmerman2025NMIHP</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Zimmerman2025NMIHP</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag Priority="0">Information science, information behavior, information disorder, misinformation, disinformation, social noise, media literacy.</SupportingTag><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-11-19T02:48:34Z</CreatedOn><UpdatedOn>2026-03-27T03:12:34Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="4"><Provenance>Public NPDS record with handle 'GFD048202' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 11/25/2025 1:15:43 AM.</Provenance><Provenance>Public NPDS record with handle 'GFD048202' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 11/19/2025 2:49:38 AM.</Provenance><Provenance>Public NPDS record with handle 'GFD048202' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/26/2026 8:12:33 PM. </Provenance><Provenance>Public NPDS record with handle 'GFD048202' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 11/28/2025 10:24:36 PM.</Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>The EPSMS Pathway: Immuno-Neuro-PET with Theranostics as a Research Framework to Find a Cure for Multiple Sclerosis</Name><Nature /><PrincipalTag>Taswell2026EPSMS</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Taswell2026EPSMS</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag Priority="0">Multiple sclerosis, auto-immune disorders, neurodegenerative disorders, entire-body PET scans, immuno-neuro-PET, theranostics, EPSMS.</SupportingTag><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-01-19T12:55:50Z</CreatedOn><UpdatedOn>2026-03-24T23:04:38Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="4"><OtherText /><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="4"><Provenance>Public NPDS record with handle 'LA7A7171C' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/24/2026 1:23:06 AM. </Provenance><Provenance>Public NPDS record with handle 'LA7A7171C' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/24/2026 4:04:37 PM. </Provenance><Provenance>Public NPDS record with handle 'LA7A7171C' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/3/2026 2:17:37 AM.</Provenance><Provenance>Public NPDS record with handle 'LA7A7171C' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/24/2026 4:04:20 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Survey, Analysis, and Requirements for Semantic Enhancement to Support Machine Understanding of Scientific Literature</Name><Nature /><PrincipalTag>Craig2020SARSE</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/craig2020sarse</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="5"><SupportingTag /><SupportingTag Priority="0">semantic web</SupportingTag><SupportingTag Priority="0">web standards</SupportingTag><SupportingTag Priority="0">literature mining</SupportingTag><SupportingTag Priority="0">scholarly publishing</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="1"><Location>&lt;div class='vcard'&gt;&lt;div class='url' href='https://www.brainiacsjournal.org/arc/pub/Craig2020SARSE/ViewPdf'&gt;https://www.brainiacsjournal.org/arc/pub/Craig2020SARSE/ViewPdf&lt;/div&gt;&lt;/div&gt;</Location></Locations><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2021-01-01T00:49:13Z</CreatedOn><UpdatedOn>2026-03-08T13:39:55Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="1"><CrossReference Priority="0">https://www.brainiacsjournal.org/arc/pub/Craig2020SARSE</CrossReference></CrossReferences><OtherTexts Count="3"><OtherText /><OtherText /><OtherText Priority="0">&lt;BibTeX&gt;@article{Adam Craig2020SARSES,   author = {Adam Craig, Peter Hong, Shreya Choksi, Anousha Athreya, and Carl Taswell}, date = {2020-12-31}, journaltitle = {Brainiacs Journal of Brain Imaging And Computing Sciences}, title = {Survey, Analysis, and Requirements for Semantic Enhancement to Support Machine Understanding of Scientific Literature}, eid = {D11DABE6D}, issue = {1}, pages = {1--9}, volume = {1}, comment = {received 2020-Dec-12, published 2020-Dec-31}, owner = {ctaswell}, timestamp = {2020-12-31}, year = {2020},}&lt;/BibTeX&gt;</OtherText></OtherTexts><Provenances Count="1"><Provenance>Public NPDS record with handle 'D11DABE6D' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/8/2026 6:39:54 AM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation><Status>Unknown</Status></PortalValidation><DoorsValidation><Status>Unknown</Status></DoorsValidation><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Biomedical Informatics Needs New Nosology for Collective, Community, Social and Public Health</Name><Nature /><PrincipalTag>Taswell2024FAIRNNN</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/taswell2024fairnnn</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2024-12-30T10:31:39Z</CreatedOn><UpdatedOn>2026-03-08T04:31:15Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="1"><Provenance>Public NPDS record with handle 'W3A8E3D23' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/7/2026 8:31:14 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>The Multimedia FAIR Metrics Grand Challenge</Name><Nature /><PrincipalTag>Craig2024MMFMGC</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/craig2024mmfmgc</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2024-05-23T09:09:04Z</CreatedOn><UpdatedOn>2026-03-08T03:10:47Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="1"><Provenance>Public NPDS record with handle 'G7ECAEAD9' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/7/2026 7:10:47 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>What Can Medical Imaging Tell Us About Multiple Sclerosis?</Name><Nature /><PrincipalTag>Craig202431WCIMS</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/craig202431wcims</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2024-07-21T05:35:26Z</CreatedOn><UpdatedOn>2026-03-08T01:06:53Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'E96583810' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/7/2026 5:06:52 PM. </Provenance><Provenance>Public NPDS record with handle 'E96583810' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/7/2026 12:30:25 AM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Brainiacs 2026 Volume 7 Issue 3</Name><Nature /><PrincipalTag>Brainiacs2026v7i3</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Brainiacs2026v7i3</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-03-06T10:55:15Z</CreatedOn><UpdatedOn>2026-03-06T23:59:56Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'N2E060370' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 2:57:33 AM. </Provenance><Provenance>Public NPDS record with handle 'N2E060370' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 3:59:56 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Brainiacs 2026 Volume 7 Issue 2</Name><Nature /><PrincipalTag>Brainiacs2026v7i2</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Brainiacs2026v7i2</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-03-06T10:54:26Z</CreatedOn><UpdatedOn>2026-03-06T23:59:06Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'CDFB2B47D' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 2:57:05 AM. </Provenance><Provenance>Public NPDS record with handle 'CDFB2B47D' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 3:59:06 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Brainiacs 2026 Volume 7 Issue 1</Name><Nature /><PrincipalTag>Brainiacs2026v7i1</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Brainiacs2026v7i1</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag /></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-03-06T10:53:07Z</CreatedOn><UpdatedOn>2026-03-06T23:57:43Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="3"><OtherText /><OtherText /><OtherText /></OtherTexts><Provenances Count="3"><Provenance>Public NPDS record with handle 'M234096C8' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 3:22:24 AM. </Provenance><Provenance>Public NPDS record with handle 'M234096C8' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 3:57:42 PM. </Provenance><Provenance>Public NPDS record with handle 'M234096C8' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 3/6/2026 2:56:18 AM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Dishonesty in Research</Name><Nature /><PrincipalTag>Wilmshurst2025DISCR</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Wilmshurst2025DISCR</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="1"><SupportingTag Priority="0">Scientific research misconduct, clinical trial fraud.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2026-01-01T06:41:58Z</CreatedOn><UpdatedOn>2026-03-05T02:45:12Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="1"><OtherText /></OtherTexts><Provenances Count="2"><Provenance>Public NPDS record with handle 'S2339W85D' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 1/1/2026 1:52:31 AM.</Provenance><Provenance>The manuscript author should be commended for his insightful paper titled, "Dishonesty in Clinical Research." It illuminates powerful examples of such dishonesty, its motivations, and its adverse impacts. The manuscript is clear, concise, well-written, and thought-provoking.
 
However, this reviewer sees several opportunities for improvement:
* The paragraph beginning, "As a research fellow, I was threatened..." leaves this reviewer yearning to learn more. An additional sentence or two vis-a-vis the actions the author took and his "why" for doing so, would be edifying, as would any brief personal comments he wishes to make about the experience. The author merits commendation for his integrity and moral courage.
* While the author cites myriad examples of specific cases of dishonesty, the manuscript would benefit from more background regarding the field of studying this phenomenon overall. Given that the manuscript is being published in the Guardians of Truth and Integrity annual theme issue of the Brainiacs journal, citations to past Guardians of Truth and Integrity published research could itself make for a compelling arc. More generally, the reader would benefit from a bit of enhanced understanding of how investigators spanning various academic disciplines have studied the overarching phenomenon.
* The author closes the manuscript by stating, "It is clear that research, particularly medical research, is in trouble from widespread falsification." A subsequent sentence or two pointing to future directions, to better understand and/or to ameliorate the problem, might make for a compelling conclusion.
 
Thank you to the author for submitting this compelling manuscript.

Public NPDS record with handle 'S2339W85D' accessed in 'Brainiacs Diristry' by user with alias 'FDEA72' on 3/4/2026 6:45:12 PM. </Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep><NexusResRep IsAuthorPrivate="false" IsAgentShared="false" IsUpdaterLimited="false" IsManagerReleased="false"><EntityMetadata><Name>Structure-Behavior-Action Framework for Coherent Scientific Enterprise</Name><Nature /><PrincipalTag>Kristanto2025SBAFCSE</PrincipalTag><CanonicalLabel EntityType="Publication">https://npds.brainhealthalliance.net/nexus/brainiacs/Kristanto2025SBAFCSE</CanonicalLabel><AliasLabels Count="0" /><SupportingTags Count="2"><SupportingTag /><SupportingTag Priority="0">Research ethics, scientific integrity, Structure-Behavior-Action Framework, NPDS Cyberinfrastructue, FAIR Metrics.</SupportingTag></SupportingTags><SupportingLabels Count="0" /><OtherEntity /><Owner /><Contact /><Locations Count="0" /><Descriptions Count="0" /><Provenances Count="0" /><Distributions Count="0" /><FairMetrics Count="0" /></EntityMetadata><RecordMetadata><CreatedOn>2025-12-07T10:14:06Z</CreatedOn><UpdatedOn>2026-03-02T19:59:35Z</UpdatedOn><Diristry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Diristry><Registry>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Registry><Directory>https://npds.npdslinks.net/nexus/npds-root/brainiacs</Directory><Registrar>https://npds.npdslinks.net/nexus/npds-root/bha-scribe</Registrar><Registrant /><Signatures Count="0" /><CrossReferences Count="0" /><OtherTexts Count="2"><OtherText /><OtherText /></OtherTexts><Provenances Count="3"><Provenance>Public NPDS record with handle 'Q273E0FA6' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 1/9/2026 10:18:46 PM.</Provenance><Provenance>### Novelty

This paper approaches systemic challenges in science through the **Structure–Behavior–Action (SBA) framework**, offering a conceptual lens derived from systems design theory. By applying this framework to the scientific enterprise, the authors provide a structural diagnosis of persistent problems regarding research fragmentation, as well as the reproducibility and replication crises. Importantly, the paper does not stop at diagnosis but proposes structural reform. Specifically, it suggests restructuring the scientific ecosystem through decentralized information systems, such as the Nexus-PORTALDOORS-Scribe (NPDS) Cyberinfrastructure, to better organize and integrate scientific knowledge. In addition, it introduces Fair Acknowledgment of Information Record (FAIR) Metrics as complementary measures to traditional bibliometrics, aiming to more accurately assess the quality and reproducibility of scientific contributions. Together, these proposals demonstrate a constructive and solution-oriented approach.

### Originality

The Structure–Behavior–Action (SBA) framework is presented as an original extension of the earlier Structure-Behavior-Function (SBF) model, which was developed for engineering design processes. The conceptual shift from “Function” to “Action” is theoretically motivated by the need to account for cognitive agents operating in complex adaptive biological and social systems. This adaptation meaningfully broadens the applicability of systems design principles beyond deterministic machines to dynamic social systems such as science itself. The reframing is conceptually innovative and provides a fresh perspective on institutional reform.

### Significance

The paper addresses two pressing and widely acknowledged challenges in contemporary science: fragmentation of research outputs and the reproducibility/replication crisis. These systemic issues significantly hinder the accumulation of reliable, cumulative knowledge. By analyzing these problems through the SBA framework and proposing structural interventions, the paper contributes to an important and timely discussion. If further developed and operationalized, the proposed reforms could make a meaningful contribution to improving the organization, evaluation, and long-term sustainability of the scientific enterprise.

### Writing and Organization

The manuscript is generally well structured, with a logical progression from theoretical framing to problem diagnosis and proposed solutions. The arguments are presented clearly, and the overall writing is accessible and easy to follow.

Public NPDS record with handle 'Q273E0FA6' accessed in 'Brainiacs Diristry' by user with alias 'XDC859' on 3/2/2026 11:59:35 AM. </Provenance><Provenance>Public NPDS record with handle 'Q273E0FA6' updated in 'Brainiacs Diristry' by user with alias 'ctaswellbj' on 12/11/2025 5:46:40 AM.</Provenance></Provenances><Distributions Count="0" /></RecordMetadata><InfosetMetadata><PortalValidation /><DoorsValidation /><NexusEntailment /></InfosetMetadata></NexusResRep></NexusService></NexusServer></NPDS>